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Re: perversely caught between insomnia and fatigue » zeugma

Posted by King Vultan on August 11, 2004, at 7:40:12

In reply to perversely caught between insomnia and fatigue, posted by zeugma on August 10, 2004, at 22:58:20

FWIW, Nardil potently inhibits REM sleep, and I do not recall having a single dream in the months I was on it at therapeutic dosages. Unfortunately, it often induces insomnia and certainly did for me, anyway. As I tapered down recently, I began encountering this REM rebound syndrome thing when I got down to around 45 mg/day. I found it relatively unpleasant, but it is starting to go away.

It seems like any drug that works strongly on norepinephrine has a tendency to inhibit REM sleep. Other possibilities for you that might help with your fatigue are Parnate or selegiline, but both of these are likely to induce insomnia (however, they do both have a significant effect on norepinephrine). It would seem easy enough to take a sedating benzo or antihistamine as a sleep aid for this, but I don't know how well these kinds of things work for you with your narcolepsy/cataplexy issues.

Todd


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