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Re: SSRI dependence?

Posted by cpallen79 on August 10, 2004, at 14:20:14

In reply to SSRI dependence?, posted by watergirl on August 9, 2004, at 22:38:08

I've wondered about this stuff myself... I don't think so in answer to your question... If the receptors downregulate, it's because the brain is saturated with serotonin/gaba... Maybe if a SSRI/gaba drug was withdrawn too quickly, the receptors would reupregulate quickly and suck up the serotonin/gaba and cause less to be available, thus causing a nasty rebound effect or simply a return of depression and/or anxiety... Who knows, these are the times when I wish chemist was around!


> Dear Chess,
> You asked:
> But wouldn't blocking reuptake of gaba cause gaba-receptors to down-regulate and thus eventually lead to dependence on Gabatril?
>
> I'm asking:
> Does blocking reuptake of Serotonin eventually lead to dependence on SSRI's?
>
> I hope someone can answer your question.
>
> By the way, I take Gabatril, a very low dose.
>
> Best Wishes,
> Cindy


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