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Effexor, Duloxetine, Milnacipran

Posted by Cecilia on August 6, 2004, at 4:51:19

In reply to Re: CYMBALTA - I am VERY afraid!, posted by bob on August 6, 2004, at 0:27:39

Anyone know what the main difference between these three drugs is? They all supposedly work on both serotonin and norepinephrine. I couldn`t tolerate Effexor at all-the smallest dose made me sick as a dog. Having tried pretty much every antidepressant available in the U.S., (as well as going to Canada for TMS) I started trying overseas drugs (with my doctor`s permission-and don`t worry, Dr. Bob, I won`t say from where). First I tried moclobemide-did nothing but make me grind my teeth. Now I`m trying tianeptine-no effects so far (one month) side or otherwise. My plan was to try milnacipran next, but now that duloxetine has actually been approved (I never thought it would) I suppose I should go for that 1st. Except, like others have mentioned, I am very afraid. Of the side effects-Effexor was like poison for me, and of the side efeects we don`t know about yet. The article on Cymbalta made a big deal about how it has been studied in 6000 people. Six thousand-that`s nothing!!!. They`re talking about taking Serzone off the market for liver failure that affects one in 250,000. I actually feel safer with non FDA approved drugs that have been around for years in other countries. Milnacipran has been around for years as an AD, but is only being studied in the U.S. for fibromyalgia. Is there any rhyme nor reason about any of these drugs, which ones get studied and for what indications, which ones get approved or not? When I asked my doctor about tianeptine, which supposedly works exactly opposite to the SSRI`s, decreasing serotonin instead of increasing it, all he could say was, well, nobody knows how any of these drugs work. Very reassuring. Can they really all just be placebos? I`m sure, like the rest of us, I`ll end up being a guinea pig for Cymbalta, because you can`t stand to live without hope. But I just can`t believe that after all these years we`ve been waiting for it they`ve only tried it on 6000 people. Cecilia

 

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poster:Cecilia thread:374053
URL: http://www.dr-bob.org/babble/20040805/msgs/374601.html