Posted by linkadge on August 4, 2004, at 14:21:15
In reply to Re:Availability in Canada, When??? (nm), posted by Maximus on August 4, 2004, at 13:02:02
Effexor affects norepinephrine reputake at *any* dose. The amount to which the norepinephrine effect is precieved is however different from person to peron.
It is true that the venlafaxine molecule shows more affinity for the serotonin uptake pumps, but the idea that it has no effect on norepinephrine till high doses is not logical. It will increase norepinephrine as soon as it reaches the brain, but it will affect serotonin more.
I could not even tollerate even low dose effexor because of a sustained increase in blood pressure, evidence of the norepinephrine effect.
Cymbalta is supposed to be more even in its affinity for serotoin and norepinephrine, but I have seen conflicting reports on the actual activity of this. This evenness does not in any way imply that is is a better drug, just different, and perhaps more suited to those with physical complaints or energy problems.
The side effect cluster will be similar to venlafaxine with perhaps more noradrenic side effects like cardiovascular side effects etc.
Drug companies always downplay cariovascular side effects as this dramatically increases their patient population, ie depressed with cardiovascular disease.
Linkadge
poster:linkadge
thread:373918
URL: http://www.dr-bob.org/babble/20040730/msgs/374046.html