Posted by King Vultan on August 3, 2004, at 19:45:51
In reply to New development that is bumming me out (longish), posted by h on August 3, 2004, at 17:15:56
There is an interaction between Celexa and cimetidine that Lexapro likely shares to at least some extent. "Mosby's 2004 Drug Guide" indicates that 400 mg of cimetidine increased the blood plasma level of a dosage of 40 mg Celexa by about 40 %. So there may be a reduction in antidepressant effect with the elimination of the cimetidine. However, if this does turn out to be the case and causes you problems, I would think you could just increase the dosage of the Lexapro a little bit.
Oncology and these types of interactions are totally outside my area of knowledge, as I don't really understand why there would be a kidney issue with Lexapro and not with some of the other drugs you mentioned. Your experience seems to indicate that an SSRI is the right kind of drug for your depression, but that you are unfortunately sensitive to the nausea side effect these drugs can cause. I believe that Celexa and Lexapro may be the two best ones that way. There are other drugs that are skewed towards serotonin as the SSRIs are, but you would need to switch drug classes, and I have no idea how compatible those drugs would be with the cimetidine.
Todd
poster:King Vultan
thread:373719
URL: http://www.dr-bob.org/babble/20040730/msgs/373779.html