Posted by zeugma on August 3, 2004, at 17:12:04
In reply to Re: correction. » zeugma, posted by Sad Panda on August 2, 2004, at 22:41:14
> > I should have said, SRI's are generally less potent AD's than MAOI's with the exception of clomipramine, which according to many is both the most potent AD and the most potent anti-obsessional.
> >
> >
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> Clomipramine is a powerful NE reuptake inhibitor too, equal to Imipramine & Amitriptyline. These three are better in monotherapy than the SSRI's becuase the increase two amines instead of just one.
>
> Cheers,
> Panda.
>
Hi Panda,What's interesting is that while these three are probably the most potent AD's overall (for what that's worth, 'antidepressant' is a term that seems both too restrictive ,<i.e. caffeine reduces suicide risk, so it must be elevating mood somehow> and too loose <what makes trazodone an antidepressant and Xanax not? Apologies to anyone who got better on trazodone alone, but is there anyone in existence who has taken the 600 or so mg a day required to get full AD effect?>), imipramine and amitriptyline are useless in various forms of OCD, social phobia, and other such disorders, while CMI has efficacy at least equal to the best of the SSRI's in this respect. AMI and IMI are SRI's, but apparently they're just potent enough to deal with depression, and not deal with these other problems.
It's all mysterious to me. Desipramine is anxiogenic, and yet it is a proven antipanic agent. And I used to consider panic disorder the paradigm of an 'anxiety-spectrum' disorder.
-z
poster:zeugma
thread:372783
URL: http://www.dr-bob.org/babble/20040730/msgs/373718.html