Posted by zeebop on July 27, 2004, at 7:16:10
In reply to Imipramine vs desipramine vs clomipramine?, posted by banga on July 27, 2004, at 0:10:08
> Hello!
>
> Can anyone elucidate what the differences are between these three drugs? Clomipramine is something my depression has responded to in the past (but if I go too high on it I gain weight), I have never tried the other two and wonder whether there would be a difference. The reason I ask is--not to become a "me too!" gal, but along with my depression and anxiety I have ADD-ish symptoms and wondered why desipramine not clomipramine has been suggested as possible treatment. Are the SE profiles different?
>
> In case youre wondering I am taking 15mg Lexapro, 25mg clomipramine, 40mg Geodon, 40mg amantadine.
>
> I'm surprised so little people take Geodon. Maybe because it's a stupid name for a drug.
>
> Anyways, thanks in advance for any thoughts....
> BangaHi,
I tried all of them and this is my experience :- Clomipramine : it has side effects like SSRIs especially sexual dysfunction and bruxism.I too gained weight when I increased the dose>All in all,it is the most potent serotonergic AD in the market after paroxetine,but has a weaker NARI metabolite.
- Desipramine : is a metabolite of Imipramine and so a potent NARI . Side effects included tremor,rapid heartbeat,aggression : did not like it .
- Imipramine : is the golden one it has nearly equal potency with regards to Serotonin and Noradrenaline + less sedative than clomipramine + not too stimulating like desipramine . side effects diminished rapidly (dry mouth,fine tremor,cold feet), unlike clomipramine,no problem with sex...so it gave me within 2-3 weeks increase in concentration,loss of obsessive thoughts,diminshed anxiety,energy,drive,natural sleep,without sexual dysfunction,aggression,bruxism,apathy.The only side effect was a slight increase in appetite and some weight gain that is dose-related.
poster:zeebop
thread:370994
URL: http://www.dr-bob.org/babble/20040724/msgs/371062.html