Posted by zeugma on July 19, 2004, at 0:22:25
In reply to WATS THE DIFFERENCE TO TCAS AND OTHERS?, posted by crazychickuk on July 18, 2004, at 18:10:29
here's everything you wanted to know about dothiepin and TCA's, and more. Is it working better than Remeron?
Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding
by
Sanchez C, Hyttel J
Cell Mol Neurobiol 1999 Aug; 19(4):467-89ABSTRACT
1.The present survey compares the effects of antidepressants and their principal metabolites on reuptake of biogenic amines and on receptor binding. The following antide-pressants were included in the study: the tricyclic antidepressants amitriptyline, dothiepin, and lofepramine and the atypical antidepressant bupropion, which all have considerable market shares in the UK and/or US markets; the selective serotonin reuptake inhibitors (SSRIs) citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline; and the recently approved antidepressants venlafaxine and nefazodone. 2. Amitriptyline has similar in vitro reuptake inhibitory potencies for 5-HT and NA, whereas the metabolite nortriptyline is preferentially a NA reuptake inhibitor. Both amitriptyline and nortriptyline are also 5-HT2 receptor antagonists. 3. Dothiepin has equipotent 5-HT and NA reuptake inhibitory activity, whereas northiaden shows a slight selectivity for NA reuptake inhibition. Dothiepin and northiaden are also 5-HT2 receptor antagonists. The slow elimination rate of northiaden (36-46 hr) compared to dothiepin (14-24 hr) suggests that northiaden contributes significantly to the therapeutic effect of dothiepin.
poster:zeugma
thread:367475
URL: http://www.dr-bob.org/babble/20040714/msgs/367616.html