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Re: Pamelor - How does it work

Posted by KaraS on July 17, 2004, at 20:47:33

In reply to Re: Pamelor - How does it work, posted by ravenstorm on July 17, 2004, at 15:24:45

> Just reread my post and can't believe how stupid I am on this remeron!! I hate it. I wrote the "long wrong" instead of the long run. I can't believe the cognitive blunting of this drug. I wasn't like this on paxil. My memory is also totally shot. Sigh.
>
> Does notrip. also cause cognitive blunting?

I know of many who call the tricyclics "dumb drugs" because of their anticholinergic effects and because they're "dirty" in the sense that they don't cleanly or directly hone in on the problem (probably not a great way of explaining it but you get the gist). Desipramine is usually excluded from that categorizition because it is the least anticholinergic and quite stimulating.

On the otherhand, I've heard of many people who have a lot more clarity (as well as relief from depression) once they've taken nortriptyline. Some people tend to be sedated on it while others find it very stimulating. I think that the more sedating, more ACh drugs are the ones with the most cognitive blunting. I wonder if those who find nortriptyline stimulating, have less cognitive blunting from it. (SLS? Todd?)


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