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Re: McMan's Depression/Bipolar Weekly: Genetics » jrbecker

Posted by SLS on July 13, 2004, at 7:34:08

In reply to Re: McMan's Depression/Bipolar Weekly: Genetics, posted by jrbecker on July 12, 2004, at 14:12:59

Hi JB.

Thanks for everything.

Right now, I'm in a bad place regarding my outlook for my own case. The more I learn about the degenerative nature of bipolar disorder, the contribution of stress, and the damage that begins in early childhood and extends throughout a chronic and unremitting depressed state (age 17-44), the less I think are my chances for getting well. It is only logical. The only ray of hope I have to hold on to is the fact that I have had several brief (less than a week) remarkable improvements in response to changes made in medication over this last year.

> By the way, some of this new research is being put into practice in early drug treatments (e.g., PDE4 inhibitors...

There is a drug called rolipram that has been used in Japan to treat depression for many years. It is also a PDE4 inhibitor. Do you know anything about this? This might be a stretch, but how might this tie in to caffeine and cGMP? Caffeine is one of the few substances that I can rely on to give me an energy boost - more so than amphetamine.

Sometimes I feel truly stupid for having hope. I feel like one of P.T. Barnum's suckers.


- Scott

 

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