Posted by Sad Panda on June 29, 2004, at 1:40:07
In reply to Re: Best dopaminergic for..., posted by Questionmark on June 29, 2004, at 1:18:42
> Paul, thanks for your suggestion. i seriously doubt i could get Desoxyn prescribed though, for one thing, and it might also be too potent and risky being on an MAOI. i am considering a low/moderate dose of either methylphenidate, dextroamphetamine, or pemoline, however. i wonder if one of these (a stimulant) would be better or worse overall than a straight dopamine agonist.
>
> Panda, i don't think nortriptyline or trazodone would be good due to their H1 blocking properties. i am so sensitive to antihistamines and never seem to develop adequate tolerance to them. i hate em. Also i can't deal with much more anticholinergic effect and so i think nortriptyline would be especially bad. i wish so much i could try something like nomifensine, but nOOOoooo, they won't keep thAt available. Anyway, thanks for your suggestions though.
>
>Clomipramine is the TCA that has the least H1 antagonism for the most 5-HT2A antagonism, but forbidden with an MAOI. Nortriptyline has about twice as much H1 antagonism, but is very mild compared to the sedating TCA's. Trazodone doesn't block H1, it gets all of it's sedative properties from 5-HT2A & A1 blockade. Not sure how much M1 antagonism Traz has, but Nortriptyline has some.
Cheers,
Panda.
poster:Sad Panda
thread:359682
URL: http://www.dr-bob.org/babble/20040627/msgs/361541.html