Posted by Keith Talent on June 5, 2004, at 23:51:00
I've read some PubMed abstracts of studies from the New York State Psychiatric Institute that found that tolerance developed only to the euphoriant effects, whilst sensitisation developed to all the other effects (psychomotor activation, jitteriness, ability to concentrate, cardiovascular effects etc.).
Posts to Psycho-Babble seem to me to lean in favour of tolerance development over sensitisation, necessitating dose increases and/or drug holidays. Does anyone know if there is a single RIGHT answer to this question?
I ask because I am currently taking 40 mg per day (total) of dextroamphetamine (was first prescribed it two months ago). It has never been an adequate dose, so tolerance hasn't arisen as an issue, but if my psychiatrist raises the dose to, say 120 mg per day, which direction will things move in:
- tolerance developing such that I will ask for further dose increases
- sensitisation, leading me to complain about side effects getting worse, and asking for the dose to be reduced?
There are some studies that found that tolerance develops, while others say that sensitisation develops.
My diagnoses are:
- Major Depressive Disorder
- Obsessive Compulsive Disorder
- Social PhobiaCurrent medications are:
- clonazepam 2 mg twice per day
- dextroamphetamine 20 mg in the morning, 10 mg six hours later and 10 mg six hours later still
- irbesartan 300 mg each morning
- sertraline 100 mg each morningAny answers, advice, tips or pointers to research would be very much appreciated.
poster:Keith Talent
thread:354178
URL: http://www.dr-bob.org/babble/20040602/msgs/354178.html