Posted by zuzu80 on May 21, 2004, at 11:13:17
In reply to Re: Why AMISULPRIDE works only for 2 days? WHY?? » Davex, posted by btnd on May 21, 2004, at 6:16:21
I think the mechansim that makes it stop lies in the fact that the dose is very low. HOWEVER, I'm by no means advocating for highr doses than 50 or 100mg.
50mg compared to the antipsychotic dose which is 400-1200mg is very low. Virtually tolerance can develop to any drug but the poop out can be significantly delayed if one takes the higher recommended doses (which for our situation will be counteractive)
Tolerance develops because the neural pathways and the structures at the synapses are VERY plastic. After some time (2 months or 4-5) the body just get it that there's something unusual here (ie continuous blockade of D2/3 autoreceptors). because of the fact that these autoreceptors are blocked the cells will build more autoreceptors ie the autoreceptors become more sensitive. Because they become more sensitive they will detect the exceeding amounts dopamine and signal to the cell STOP RELEASE of dopamine. DAMN autoreceptors!
Another possibility is that because of the more dopamine, the threshold of activating the recieving cell rises (ie it becomes less sensitive to dopamine).
I heard about someone who used it for 4-5 months then pooped out. After she resumed it 3 months later it functioned perfectly as before.
Maybe taking it for 3 weeks then 1 week without and then resuming it might prevent tolerance ???? Try it and see.
Wish me luck with the doctor on monday, hope he will RX it. I have a strategy though, I will suggest it to replace Klonopin, he will love me getting off it!
Hugs,
Christine
poster:zuzu80
thread:348888
URL: http://www.dr-bob.org/babble/20040521/msgs/349225.html