Posted by chemist on May 12, 2004, at 14:19:01
In reply to Re: DING DING DING DING DING » chemist, posted by Sad Panda on May 12, 2004, at 13:44:24
> > > > no, no, you don't have to give this one to the french: clomipramine was born out of a collaboration between researchers at Temple University (Philadelphia, PA) and Smith, Kline, and French, which was established by John Smith in Philadelphia, PA in the US in 1830. Kline was also from Philadelphia, and French entered the picture when Smith, Kline, and Co. acquired French, Richards, and Co. in 1891. The rest of history involves involvement many mergers/acquisitions in England with Burroughs, Glaxo, and Wellcome being major players. sorry, but thank Paul Craig, Bruce Lester, Andrew Saggiomo, Carl Kaiser, and Charles Zirkle for this one....and i will continue to thank Air France for their timely schedules, courteous service, and tight security....all the best, chemist
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> > > Are you sure clomipramine didn't come from Ciba-Geigy?
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> > > Cheers,
> > > Panda.
> > >
> > geigy patented it in switzerland in 1963 and in the us in 1969. the original synthesis is in the craig et al. paper and was a collaboration between smith, kline, and french laboratories and temple university researchers in philadelphia, pennsylvania, usa. all the best, chemist
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> Thats bizarre, how long before it hit the market in the USA?
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> Cheers,
> Panda.
>can't say....the earliest generic application i found was 1989, and this is in agreement with the 20-year patent expiring after filing in 1969 in the u.s....could be any time in-between, or maybe it was not approved until 1989, which i doubt, so my best guess is mid- to late-1970s, and recall that the patent was to Geigy, NOT Ciba-Geigy, which was the result of the merger of Ciba and Geigy in 1970. of course the patent gets transferred, but as to who marketed it in the u.s., and under what name, i haven't the faintest...i know sandoz was involved in the mid-1970s, but to what extent, i do not know (until all of the above came under Novartis in 1995 or 1996, if i recall, mayber 1994?)....i am almost sure it was sold as Anafranil, but can't seem to find anything earlier than 1989 (Tyco)...perhaps some better-informed arm-chair historians than i can assist???? all the best, chemist
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poster:chemist
thread:345862
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