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Re: SSRI substitute » jms600

Posted by harryp on May 4, 2004, at 15:09:51

In reply to SSRI substitute, posted by jms600 on May 2, 2004, at 16:12:21

There's some good advice here. You implied that the SSRI's were working for you, so my feeling is that you should just try adding a stimulant. Adding a tricyclic would make more sense if you were still depressed.

You might want to try phasing out the SSRI in favor of a serotonergic TCA like protriptyline. Desipramine probably has the best SE profile of the TCA's, but it has no effect on serotonin, and the fact that the SSRI's work for you suggests that you should stick with an AD that has some serotonergic effect. Keep in mind that some people have hellish SE's on the SSRI's and no problem on the TCA's--published SE profiles are just averages, and you might experience few problems with a TCA.


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