Posted by Sad Panda on April 30, 2004, at 10:39:08
In reply to Nardil anticholinergic vs. adrenergic SEs, posted by Questionmark on April 30, 2004, at 3:54:28
> 1) DO MAOIs (esp. Nardil) have anticholinergic properties?
Given that MAOI's raise levels of all neurotransmitters, I would say they are procholinergic & proadrenergic to some degree. :)
> 2) Are there adrenergic effects that can be subjectively similar or identical to anticholinergic effects?
I don't think so, but I'd actually have to look it up. I know what agonism & antagonism does at some receptors, the ones that differentiate non-MAOI drugs. ie: Alpha 1 NE blockade causes orthostatic hypotention & reflex tachcardia, but what does agonism do? Ach-Muscarinic blockade causes memory problems, dry mouth, increased eye ball pressure & constipation, but what does agonism do?, cause drooling & diarrohea? :)
SSRI's raise serotonin which causes extra agonism at all 5-HT receptors. 5-HT1 receptor agonism is believed to be what causes an AD effect. 5-HT2A agonism causes excess REM sleep & vivid dreams, antagonism increases deep sleep & may be anxolytic. 5-HT2C is tied to sexual function, agonism causes anorgasmia, antagonism reverses it & is said to be anxiolytic by some. 5-HT3 agonism causes nausea.
I will have to look up what others do, anyone got a good site?
Cheers,
Panda.
poster:Sad Panda
thread:341646
URL: http://www.dr-bob.org/babble/20040429/msgs/341765.html