Posted by Flipsactown on April 14, 2004, at 18:18:39
In reply to Re: Nardil sleep quality, posted by zeugma on April 14, 2004, at 13:46:39
I just started Nardil 5 days ago, rx 15mg daily for 2 weeks, 30mg daily thereafter. I noticed the insomnia immediately but I do not seem to miss it. However, as I am still depressed I find myself trying to sleep in order to escape the pain of depression. As I am now suffering from insomnia, I am afraid that I will get even more depressed as sleeping was a coping mechanism I used to cope with depression. When will Nardil kick in? I hope soon as I don't want to get even more depressed because of insomnia. I have unipolar depression from chronic back pain and have been on ADs for over 13 years. Thanks.
FST
> Todd/KV's guess is correct, that SSRI's suppress both REM and SWS (slow wave sleep) leading to easy arousal and also for the tendency for dreaming to 'migrate' to lighter stages of sleep where they are easy to recall.
>
> I am not sure about the effect of dopamine on sleep, but norepinephrine appears to be the neurotransmitter that most directly regulates REM: the locus coeruleus must cease firing for the brain to enter a REM state, and selective NE reuptake inhibitors block REM without also blocking SWS.
>
> I read a study which said that Nardil did not interfere with SWS. This would present a strong contrast with SSRI's, and is one reason why I believe MAOI's (and TCA's) to be far superior medications for the long term treatment of depression.
poster:Flipsactown
thread:336279
URL: http://www.dr-bob.org/babble/20040412/msgs/336436.html