Posted by chemist on April 9, 2004, at 23:08:45
In reply to Questions for Chemist - Pregabalin and Zoloft, posted by BobS, on April 9, 2004, at 19:53:03
> Do you know what Pregabalin will help with, e.g. mild OCD and/or atypical depression? What might its indications be and then "off label" uses?
>
> As to Zoloft, my pdoc is big on Zoloft for me. DX "harm avoidant OCD/atypical depression (mood reactivity and rejection sensitivity). Let's throw in some social phobia and panic when I was much younger. Any thoughts on Zoloft vs. the universe of meds?
>
> Currently, on alprazolam, but due to a year of strong exogenous stressors had to go from 1.5 mg per day to 3.5 mg per day and still need help.
>
> I am going to go to Zoloft, no choice, but hope Pregabalin (if it ever is approved) can replace the Zoloft. BTW, was on Paxil and Prozac earlier and had a horrible time with them.
> Thanks,
> BobS.hi bob...pregabalin has a somewhat shaky history in terms of making it through phase II trials, yet there are literature that support the upside of this med, which will most likley be found to act on GABA_{A} and GABA_{B} receptors in addition to being indicated for calcium-dependent ion channel gating. pfizer is having a bit of a rough go at it and will refile an NDA (if not already) for approval next year. as for zoloft, it is one of the many early-generation SSRIs that can more or less ameleorate your symptoms. it is not nearly as activating as prozac or paxil, and i am concerned about you pushing the limit on alprazolam: 3.5 mg qd is going to present you with a challenge to taper, and the previous post - suggesting klonopin - is right on target. it sounds to me that you are in the mix of OCD/social phobia/and dysthemia, and i think that the anti-depressant activity of xanax is actually contributing to your overstimulation. bottom line: wait until the pros have given the green light on pregabalin - if ever - and in the meantime, taper xanax with a parallel titration of klonopin. xanax + zoloft is overstimulating, and 3.5 mg qd of xanax is going to *really* test your endurance in re: withdrawl. do keep in mind that for OCD - which is really real - there are alternatives such as celexa or, more appropriately, lexapro, but i am not dismissing zoloft for you if it does the trick. the problem is xanax and need to be remedied a.s.a.p. give me a shout.....best, chemist
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