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Re: Cytochrome P450 interaction links » Lightshifter

Posted by jane d on March 26, 2004, at 12:35:59

In reply to Concurrent use of 2 Drugs Metabolized by 2d6 Enzym, posted by Lightshifter on March 24, 2004, at 20:37:33

http://medicine.iupui.edu/flockhart/
for a list of interactions and footnotes. This site will also create pub med queries on specific drugs. The site has added a lot since I last looked at it.

http://www.acnp.org/G4/GN401000086/Default.htm This has an explanation of how it works.

I'm not sure that it's possible to get anyone to say that drug 1 is actually interacting to a significant degree with drug 2 in a specific person since there will always be other substances involved and since people differ in the amount of these enzymes they start with. Certainly many of the predicted interactions don't always occur. I've taken prozac and codeine for instance (with fingers crossed I'll admit) and had no problem.

Jane


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