Posted by rod on March 20, 2004, at 7:07:09
In reply to Re: Adderall made me quit smoking ,Why? please exp » asian girl, posted by scott-d-o on March 20, 2004, at 7:01:04
> Since the addictive nature of nicotine relies on dopamine binding to these receptors, and nicotine does not have the ability to "knock" the ligand off of these occupied receptors, the pleasure/reward from smoking a cigarette is almost entirely abolished; dependant on the dosage of the stimulant of course.
Isnt it that Nicotine exert its dopaminergic effect, by faciliating the release of Dopamine indirectly by stimulating nicotinic acetylcholine receptors? A directly dopaminergic drug would just replace the indirect effect of nicotine in my opinion.
Roland
poster:rod
thread:324612
URL: http://www.dr-bob.org/babble/20040319/msgs/326360.html