Posted by zeugma on March 16, 2004, at 16:42:04
In reply to Re: replacing nortriptyline with remeron? » zeugma, posted by Sad Panda on March 15, 2004, at 10:09:59
> I take Remeron. It's the most potent H1 blocker available. It's nearly double the strength of Doxepin, 10x the strength of Amitriptyline & 50x stronger than Nortriptyline. 15mg is heaps for sleep, a lot of people get by on just 7.5mg. The amount required just for sleep probably means that it doesn't have much affect on any other receptors. If you are looking for H1 + 5-HT2A for sleep, you may be better off with low dose Trimipramine or Doxepin.
>
> Cheers,
> Panda.The potency of Remeron for H1 is staggering (literally!). 75 mg nortriptyline = 15 mg amitriptyline = 1.5 mg Remeron. I already am fighting constant fatigue, feel a lot of weakness, have residual ADD symptoms, etc., and nortiptyline is practically a stimulant compared to Remeron.
since remeron is only slightly more potent than nortriptyline for the 5HT-2A receptor, and I can certainly tolerate a much higher dosage of nortriptyline than Remeron, I might stick with my favorite secondary amine TCA for the time being. I can't deal with a higher level of sedation than I already have, and I feel that my brain chemistry is precariously balanced as regards the sleep/arousal continuum. Remeron, or even amitriptyline, might tip it too far in the direction of somnolence.
poster:zeugma
thread:324271
URL: http://www.dr-bob.org/babble/20040313/msgs/324989.html