Posted by Tony P on March 12, 2004, at 17:21:23
In reply to TRAZADONE hangover??, posted by Janelle on March 12, 2004, at 15:53:02
> Seroquel is losing its efficacy as a sleep aid for me and I'm thinking of asking my pdoc next appointment to take me off it and switch to Trazadone. However, I know a few people who say they have awful hangovers in the morning from Trazadone -- I'd like to hear from anyone here who has taken or is taking Trazadone for sleep? What dosage is effective for you and did or do you have hangovers the next day? Thanks!
-------------------------Initially, Trazadone 50 mg was quite effective and natural-feeling; it just gave me a slight hangover. I eventually had to escalate to 100-150 mg, which definitely made it hard to get out bed after 8 hrs. There seems to be a fair bit of individual variation on this - I have a friend who took it for years with no hangover problem.
It may depend on the state of your liver, and what other meds you take. Trazadone is (I understand) metabolized by the same enzyme that looks after some common OTC's such as tylenol and dextromethorphan, as well as some Rx's, so I suppose there might be some competition slowing the clearance rate.
Tony P
poster:Tony P
thread:323681
URL: http://www.dr-bob.org/babble/20040308/msgs/323699.html