Posted by King Vultan on March 7, 2004, at 18:04:26
In reply to Question about noredenic receports (smart people), posted by linkadge on March 7, 2004, at 17:40:18
> I am taking effexor but I am also taking a beta blocker atenolol. Will the atenolol completely negate the noradrenic effects of the effexor or are there other receptors that will benefit from higher noradrenic agonism.
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> Basically I am contemplating changing to an SSRI and atenolol, and am wondering weather there will be any difference.
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> Linkadge
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>Noradrenergic agonists stimulate both alpha and beta adrenergic receptors. In both cases, there is the potential for cardiovascular and cognitive/emotional interactions. Taking the beta blocker will not necessarily completely negate the therapeutic benefits of stimulating beta adrenergic receptors, but it may reduce them to some degree. It really depends on the individual and the dosages of the drugs involved. Regardless, the alpha adrenergic interactions will still remain because there is no alpha blocker involved in this scenario.
I think there is a good chance you would notice a difference between Effexor + atenolol and an SSRI + atenolol, despite the beta blocker negating some of the therapeutic effects of the Effexor. The higher the dosage of Effexor you are on, and the lower the dosage of atenolol, the greater the likelihood you would notice a difference.
Todd
poster:King Vultan
thread:321715
URL: http://www.dr-bob.org/babble/20040304/msgs/321723.html