Posted by sb417 on March 5, 2004, at 2:02:16
In reply to Re: Anyone suffer paradoxical depression with TCAs?, posted by King Vultan on March 4, 2004, at 8:17:25
> > > IMO, SSRIs would be more likely to cause a paradoxical depression than tricyclics in general. Why? The initial target of SSRIs is the presynaptic serotonin 1A receptor, which is inhibitory. Blocking serotonin reuptake causes these receptors to be pummelled with serotonin. If a person is so depressed that their serotonin neurons aren't really firing anyway, a person won't notice any immediate change in mood, but if a person's serotonin neurons are still firing at a moderate level, the stimulation of these inhibitory 1A receptors may cause the serotonin neuron to slow down its firing rate, triggering a worse depression.
>
>Todd, that is very interesting. How would you explain a somewhat favorable response to an ssri initially, but a severe worsening of the depression 10 days to two weeks after starting the ssri?
poster:sb417
thread:319923
URL: http://www.dr-bob.org/babble/20040304/msgs/320497.html