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Re: NE reuptake inhibition

Posted by djmmm on February 25, 2004, at 13:55:11

In reply to NE reuptake inhibition Sad Panda, posted by Questionmark on February 25, 2004, at 1:19:05

> > You can add TCA's to MAOI's too. Nearly anyone can be added except Clomipramine & I wouldn't use Imipramine. Anything that is a NE reuptake inhibitor can actually help prevent a tyramine induced hypertensive crisis because tyramine is blocked at the NE reuptake sites.
>
> Cheers,
> Panda.
>
>
> That last piece of advice there is really good to know. Thanks. i was wondering why reboxetine was supposedly good for preventing hypertensive crises.
> This doesn't mean that a NRI would be useful for reversing a hypertensive reaction though, right? Cuz much of the tyramine would already be inside the noradrenergic neurons?

Reboxetine has only been studied with Parnate...a non-hydrazine MAOI, I doubt it is safe with Nardil


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