Posted by Chairman_MAO on February 7, 2004, at 13:03:19
In reply to ssri + kava? is it safe? please help!, posted by matthhhh on February 6, 2004, at 14:45:28
I combined lexapro with Kava Kava, up to 740mg kavalactones/day with no ill effects (except my psychiatrist being convinced I was on methadone or heroin toward the upper end of the dosing range!). I do not recommend doing that for long periods of time due to hepatotoxicity and "kava dermopathy".
NOTE: In addition to the GABAnergic effects you mention, Kava has a lot of overlap with mood stabilizers, in that it is a Na+ blocker and a Ca+ blocker. It's also a 5ht1a agonist and modulates glutaminergic neurotransmission.
poster:Chairman_MAO
thread:310210
URL: http://www.dr-bob.org/babble/20040204/msgs/310521.html