Posted by Viridis on January 19, 2004, at 22:27:38
In reply to Re: Wellbutrin SR- IM SCARED! Is it any good? » 8 Miles, posted by Simcha on January 19, 2004, at 13:14:22
According to GSK, splitting the SR tabs is fine. They even faxed me graphs of release rates of split vs. intact pills -- the release rate of the active ingredient is just slightly higher in the first 15 minutes for the split tabs, and then everything evens out.
The slow release is based on the fact that the WB is imbedded in a wax matrix that dissolves slowly. The coating of the pill has nothing to do with it (this is from a conversation with one of the people who developed the SR version).
The one thing to avoid is dividing many tabs at once, since they can then take up water from the atmosphere, which degrades the active ingredient. They recommend only dividing a couple of days' worth at a time for this reason.
poster:Viridis
thread:301910
URL: http://www.dr-bob.org/babble/20040118/msgs/302986.html