Posted by zeugma on January 14, 2004, at 19:36:03
In reply to Re: Norepinephrine and Concentration, posted by SandyWeb on January 14, 2004, at 11:14:35
Remeron is an NE-alpha-2 antagonist. Alpha-2 receptors are inhibitory, therefore blocking them de-inhibits, that is, causes more NE to be released.
Strattera, and many TCA's, are NE reuptake inhibitors, which cause more NE to be available in the synaptic cleft. This is analogous to the way SSRI's increase the availability of 5-HT.
NE reuptake inhibitors have been known for a long time to be efficacious in the treatment of ADD, albeit possibly less so than psychostimulants. I find Strattera's main effect to be the promotion of mental clarity. I'm curious if anyone has had this effect from Remeron.
poster:zeugma
thread:300574
URL: http://www.dr-bob.org/babble/20040114/msgs/300867.html