Posted by Francesco on January 10, 2004, at 17:47:55
In reply to Who takes tricyclics?, posted by femlite on January 10, 2004, at 16:37:28
> I have read some interesting info on tricyclics, but am curious as to why so few people take them. Are they passe and therefore underprescribed? OR considered ineffective?I don't think they're considered ineffective, quite the opposite, but they're believed to have a worse side-effects profile compared to SSRIs.
However many people found them more tolerable and I'm one of them. I have had a long experience with clomipramine, which is considered the worst in term of side-effects but I did take it for years while I could not stand an SSRI for more than six months (prozac 6 months, celexa 2 months, paxil two months). What is most important is that secondary amines are considered best in term of side-effects. This is the reason why now I'm going to start desipramine.> I am thinking about amitriptyline as an AD as I also have problems with chronic pain.
I have took it for a while but it was so many years ago I can't remember nothing about it.
What follows is a table of the side-effects of TCAs whic was sent me by Psychobabble's fellow.
It comes out that amytriptiline is one of the worst offender but I have heard it's used at low doses for chronic pain ... another issue is the antidepressant dosage though. Good luck !PERRINE
(Listed from least to most tolerable in the general sense)
Amitriptyline (tertiary amine TC)
_Weight Gain: High
_Sedation: High
_Anticholinergic: High
_Hypotension: High
_Cardiotoxicity: HighClomipramine (tertiary amine TC)
_Weight Gain: Medium
_Sedation: Medium
_Anticholinergic: High
_Hypotension: Medium
_Cardiotoxicity: HighMaprotiline (secondary amine TC)
_Weight Gain: Medium
_Sedation: Medium
_Anticholinergic: Medium
_Hypotension: Medium
_Cardiotoxicity: MediumDoxepin (tertiary amine TC)
_Weight Gain: Medium
_Sedation: High
_Anticholinergic: Medium
_Hypotension: High
_Cardiotoxicity: MediumImipramine (tertiary amine TC)
_Weight Gain: Medium
_Sedation: Medium
_Anticholinergic: Medium
_Hypotension: Medium
_Cardiotoxicity: HighAmoxapine (secondary amine TC)
_Weight Gain: Medium
_Sedation: Low
_Anticholinergic: Low
_Hypotension: Medium
_Cardiotoxicity: MediumDesipramine (secondary amine TC)
_Weight Gain: Medium
_Sedation: Low
_Anticholinergic: Low
_Hypotension: Low
_Cardiotoxicity: MediumNortriptyline (secondary amine TC)
_Weight Gain: Medium
_Sedation: Low
_Anticholinergic: Low
_Hypotension: Low
_Cardiotoxicity: Medium-----------------------------------
GORMAN
Imipramine
_Anticholinergic: XX
_Sedation: X
_Insomnia: X
_Weight Gain: XX
_Dizziness: XXDesipramine
_Anticholinergic: X
_Sedation: -
_Insomnia: X
_Weight Gain: X
_Dizziness: XXAmitriptyline
_Anticholinergic: XXX
_Sedation: XX
_Insomnia: -
_Weight Gain: XX
_Dizziness: XXNortriptyline
_Anticholinergic: X
_Sedation: X
_Insomnia: X
_Weight Gain: X
_Dizziness: XDoxepin
_Anticholinergic: XX
_Sedation: XX
_Insomnia: -
_Weight Gain: XX
_Dizziness: XXTrimipramine
_Anticholinergic: XX
_Sedation: XX
_Insomnia: -
_Weight Gain: XX
_Dizziness: XXProtriptyline
_Anticholinergic: XXX
_Sedation: -
_Insomnia: XX
_Weight Gain: -
_Dizziness: XMaprotiline
_Anticholinergic: X
_Sedation: XX
_Insomnia: -
_Weight Gain: X
_Dizziness: X
------------------------------------------------------SMITH
http://www.umich.edu/~pharm660/addrugs.pdf
Amitriptyline
_Sedating: +++
_Anticholinergic: +++Doxepin
_Sedating: +++
_Anticholinergic: +++Imipramine
_Sedating: ++
_Anticholinergic: ++Desipramine
_Sedating: ++
_Anticholinergic: +Nortriptyline
_Sedating: +
_Anticholinergic: ++Protrityline
_Sedating: 0
_Anticholinergic: ++
--------------------------------------------
poster:Francesco
thread:299074
URL: http://www.dr-bob.org/babble/20040109/msgs/299124.html