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Re: anyone had success with desipramine for adhd ?

Posted by zeugma on January 9, 2004, at 16:24:57

In reply to anyone had success with desipramine for adhd ? , posted by Francesco on January 9, 2004, at 8:37:45

> I started today desipramine to target adhd syntoms on a very low dose (10mg). I found it activating and I feel more concentrated ... Moreover my mood is better than normal even if I don't feel hypomaniac or close to it. Did anyone had success in the long term with desipramine, expecially for adhd ? Which side-effects should I have to expect ?
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> Moreover my p-doc suggested that I could take also Remeron at night ... I can't understand the rationale of it since he seems to agree that I don't have a 'serotonin problem', since serotoninergic meds make me hostile. Does somebody see some reason for taking it I can't see ? Was it prescribed just to put me asleep in case desipramine resulted to be too activating ?
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> Thanks, I would continue to post about desipramine since so far it seems to be the only AD which doesn't make me feel worse from the very first day. Recently I tried Imipramine (10mg) but it made me angry.
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remeron is actually antiserotonergetic. It blocks serotonin 2 and 3 receptors potently.

A little advertised fact is that many antidepressants are better described as "antiserotonergetic" than "serotonergetic." Many are both at once, like amitriptyline, and it is reasonable to think that this is partly responsible for the fact that no single AD seems more effective over a wide range than amitrip.
If SRI's make you moody then maybe Remeron would help, but desipramine by itself shouldn't set off serotonin-related problems.

I've read reports of ADHD adults responding favorably to a very low dose of desipramine.

Did imipramine cause a lot of side effects? Desipramine is supposed to cause much less in the way of s/e, and to be, as your pdoc seems to worry, a lot more activating.


A lot of people say you can't tell a lot from the first day or two... Zoloft and Wellbutrin and Prozac made me sick from the day I tried them (Zoloft most severely as I described in another thread) and the problems i've had with klonopin set in within hours of taking the first dose. On the other hand nortriptyline felt OK the first day, and Strattera felt very alerting, and I continue to take both drugs with great success and minimal side effects.You should trust your instincts when it comes to these drugs.


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poster:zeugma thread:298482
URL: http://www.dr-bob.org/babble/20040109/msgs/298752.html