Posted by scott-d-o on January 7, 2004, at 22:50:04
In reply to Zyprexa versus Geodon/Abilify for SEDATION, posted by bipolarspectrum on January 7, 2004, at 11:25:11
> Hi,
> I'm currently on Zyprexa (5mg) + Prozac (5mg) for major depressive disorder with a hint of bipolar (anti-depressant associated mania). I'm experiencing strong sedation and mental 'clouding' from the zyprexa and I was wondering whether anyone had less sedation and clouding from Abilify or Geodon??
> ThanxGeodon at it's lowest available dosage (20mg) caused me to feel completely spaced out. My pdoc told me Abilify is even worse for sedation, so I didn't even attempt to go there. I only took Geodon for one day so perhaps these effects subside after continued use, however, I just couldn't afford to give it a fair trial due to work/college. Haven't tried Zyprexa so I can't provide any comparative data. The only other antipsychotic I have tried is sulpiride which caused no mental problems for me at dosages up to 150mg/day.
This makes me think this effect is mainly a result of antagonism at 5-HT receptors (specifically, the 5-HT2a receptor), since sulpiride and amisulpride act exclusively at DA receptors. Unfortunetly, it's not available in the USA.
Hope this helps,
scott
poster:scott-d-o
thread:297610
URL: http://www.dr-bob.org/babble/20040105/msgs/297887.html