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Re: ZOLOFT - Dopamine???

Posted by zeugma on January 1, 2004, at 16:04:26

In reply to Re: ZOLOFT - Dopamine???, posted by scott-d-o on January 1, 2004, at 13:55:06

> Sertraline's ability to inhibit the DAT (dopamine transporter) is so weak in comparison to the SERT inhibition that after long term usage it has been shown to actually *increase* the activity of the DAT. This is why some people develop bruxism (teeth-grinding) as a result of SSRI usage.
>
> If you are worried about dopamine you can always augment with buspirone (not a hard med to get due to virtually no abuse potential). Buspirone is a 5-HT1a agonist which causes release of dopamine and should also attenuate sertraline's ability to raise extracellular serotonin.
>
> scott


My experience with buspirone was that it increased the 'mood-elevating' effects of my AD (nortriptyline) almost immediately. Of course this is contrary to what most people report about an up to 8-week latency period. It does help me with bruxism, even though mine isn't due to AD use, so it should be helpful with AD-induced bruxism as well. It has a mild calming effect.

The reason so many are dissatisfied with it, and have had to turn to benzodiazepines, is because it does virtually nothing for social anxiety or higher levels of general anxiety.


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