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Re: Shaky hands - how to explain to people?

Posted by scott-d-o on December 23, 2003, at 22:23:20

In reply to Re: Shaky hands - how to explain to people? » scott-d-o, posted by Laree on December 23, 2003, at 18:28:07

> Scott,
> I have another question for you. Doesn't Adderall release dopamine & Wellbutrin prevent reuptake of it?? I am really confused there. Could the Wellbutrin (which supposedly works with norepinephrine and dopamine) be blocking the Adderall's dopamine release??? Or does the Wellbutrin release even more dopamine? Again, really confused, and you seem to have a plethora of technical information on how meds work with brain chemicals. Thanks!

Reuptake is when a neurotransmitter that is already in the synapse (i.e. it has been released) is transported back up into the cell. Therefore, blocking dopamine reuptake actually allows the dopamine to sit in the synapse longer. Releasing dopamine and blocking its reuptake should have a synergistic (additive) effect since you are not only releasing the transmitter, but also preventing it from being "recycled" by the cell.

Wellbutrin very weakly blocks the reuptake of both dopamine and norepinephrine, and releases norepinephrine. As a stimulant it pales in comparison to the Adderall which is a strong DA/NE reuptake inhibtor and also causes massive release of these transmitters. Really I don't see any problem with what you are taking except the Wellbutrin seems unnecessary because it has almost the same action as the Adderall, but is not nearly as powerful.

scott


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poster:scott-d-o thread:289864
URL: http://www.dr-bob.org/babble/20031219/msgs/293005.html