Posted by mattdds on December 18, 2003, at 12:42:41
In reply to Re: Doctor gave me a PLACEBO? » Zabadoo, posted by Larry Hoover on December 18, 2003, at 10:34:17
Hey Larry,
First off, what's up man? How's the sleep issue?
I'm not sure if you know, but I trialed Parnate back in August, and stayed on it for about a month. I worked up to 40 mg daily, and I swear, I was having a positive response to it. I felt more motivated, mood was enhanced and everything was going well. Concentration was excellent.
Then, I started getting high blood pressure. They weren't exactly spikes, but more like waves where my BP would rise slowly to about 185/100, pretty high considering my baseline is normal 120/80. Interestingly, this would happen only in the afternoon...in the morning, my blood pressure would tend to run *lower* than baseline (sometimes like 105/60!).
These episodes were not related to food...I followed the dietary requirements to a T. One day I even tried fasting and it still happened. This seemed to rule out a tyramine reaction.
Anyway, my doc promptly pulled me off of it (bummer), and when I asked about a Nardil trial, he said it would do the same thing (i.e. create BP problems).
Hmm, I always wonder if he was just talking out his ass here, or didn't know the real answer, because I see abstracts regarding spontaneous *tranylcypromine* HTN episodes, but not with phenelzine or other hydrazine derivatives.
Tranylcypromine has some known intrinsic indirect acting sympathomimetic / vasopressor effects, if I'm not mistaken, and phenelzine does not. Am I right here?
Just want to get some good info, because I responded so well to Parnate that I really was wanting to try Nardil, and I didn't think the rationale for not letting me try it (i.e. it would do the same thing as Parnate) was well founded. Even if it was, I could always monitor BP readings and see, but my doc was pretty adamate. Bummer. Only issue with switching docs is he is the only guy that will prescribe Klonopin, so I don't want to wreck a good thing. Plus, overall, I'm happy with him.
Any thoughts?
TIA (thanks in advance, not transient ischemic attacks ;))
Matt
poster:mattdds
thread:291204
URL: http://www.dr-bob.org/babble/20031213/msgs/291311.html