Posted by scott-d-o on December 15, 2003, at 23:55:12
In reply to D2 and D3, posted by DSCH on December 15, 2003, at 22:06:40
> What do these receptors trip off when they are stimulated?
Amisulpride is an anti-psychotic med, meaning it doesn't "trip off" anything, it actually does just the opposite. It is a dopamine antagonist which means it sits on the receptors dopamine itself usually binds to and does nothing except block dopamine from attaching to that receptor.
> Is there a dose threshold in the neuropharmacology? I don't understand SLS's notation of (pre > post) for amisulpride in his chart.
I'm assuming this means that it preferentially blocks presynaptic receptors more than postsynaptic. Since the cell uses the presynaptic receptors to gauge how much dopamine is already in the synapse and therefore how much should be released, this has the inverse effect of increasing dopamine release. Amisulpride has this effect at 50 to 200mg, then it supposedly starts to antagonise the postsynaptic receptors just as much as the presynaptic (autoreceptors) thus *decreasing* dopamine release. Hope this helps.
scott
poster:scott-d-o
thread:289676
URL: http://www.dr-bob.org/babble/20031213/msgs/290344.html