Posted by zeugma on December 14, 2003, at 14:52:27
In reply to Help ME- whats wrong with me????, posted by smittay17 on December 14, 2003, at 12:51:03
> i was fine on Imipramine for years it cured my OCD and Panic Disorder for 6 years. I even have mild touretttes.
>
> i have to switch off the imipramine because it is swelling my tongue and causing sleep apnea.
>
> so im on (right now) 100mg Imipramine, 40mg Celexa, 75mg Desipramine (my doctor wants to eventually eliminate the Imipramine)
>
> i am feeling SO SO shaky and jittery and over nervous and scared. i can't relax. Imipramine used to make me sedated and sleepy, now i cant sleep at all or relax or even just have a quiet afternoon with my wife! im so anxious.
>
> please somebody help me and suggest something. do i have too much serotonin or too much norepinephrine? what should i do. im only seeing a primary care physician and i can't find a good psychiatrist/neurologist north of Boston.
>
> if you have any help PLEASE post in this thread or email me at smittay1975@hotmail.com . i know most of you have been through stuff and im just dying here... please help me get my life back :(
>
> erik
There are many possibilities. I was making my recommendation based on the fact that both imipramine and nortriptyline have a 'sedating component,' H1 blockade, that both celexa and desipramine lack. That's neither NE nor SER. In theory, 40 mg celexa should be adequate serotnin reuptake blockade... lexapro is more potent and you could try 10 or 20 mg of that instead.I think you had said earlier that Celexa wasn't enough by itself to remit your depression. That suggests to me that it's the dual action of imipramine that was helping you... of course it's impossible to measure the ratios in your CNS of reuptake blockade, so it's going to be guesswork on the part of your dr. (even a knowledgeable one). I would say that nortriptyline is less likely to cause jitteriness than desipramine, while still complementing the Celexa (going by your previous statement that celexa by itself didn't work).
poster:zeugma
thread:289658
URL: http://www.dr-bob.org/babble/20031213/msgs/289709.html