Posted by linkadge on December 9, 2003, at 19:47:11
In reply to Antagonism -VS- Reuptake differences w/ AD's?, posted by john1022 on December 9, 2003, at 13:39:41
You've asked quite a few questions, and I'll see how I can help.
For starters, when you restart an antidepressant, many times it will work, but it takes a lot longer to kick in for the second time. When you say you felt 100% better, you were remembering how you felt on your final dose, not your first dose.I quit Celexa, and when I restarted it, it took a good 6 months to get back to where I was when I quit it. When you restart a drug, it doesn't start where it left off.
Secondly I had a similar reaction to starting Celexa for the second time. I was feeling so crappy that when I started it for the second time
I thought I would feel 100% immediately, because I could *remember* what It like to feel 100% before I actually felt 100%, thats my theory as to why it made me manic.After a few months, that normalized, and I remembered what normal was. So if you are going to try effexor again, I would stick it out.
Perhaps combine it with a sleeping pill, or trazodone, which is a ht2a repecptor antagonist.
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As far as your concerns about how the receptors work is like this. All the brain receptors are constantly chaning their density and affinity in responce to how much neurotransmitter they are receiving.Insomnia can be caused by multiple neurotransmitter imballences. As a rule of thumb, when a drug makes you feel better, sleep is normally the result. Even effexor which initally activates the receptor, can improve sleep in depressed patient because of its ability to work as an antidepressant.
Anyhow, the insomnia tends to lessen as time progreses because the recptor itself adjusts itself to the increased availabliltiy of serotonin, and improved sleep comes with time.
If you take a drug like rememeron, it will initally make you feel very drowsy irritable and sluggish, because it will block the 5ht2a receptor. But over time, the receptor adjusts itself to the decreased availability of serotonin, and the overdrowsyness will subside.
I personally don't recomend Remeron, while it did help sleep very much, it wasn't a good antidepressant for me, it did not help my mood very much. (that doesn't mean it won't help you)
My advice is this: If effexor worked, then go back to effexor. The longer you stick with it the more your brain will re-recognize how it behaved with it. If you feel manic on it then lessen the dose. If you were really bipolar then you probably woul've gone truely manic the first time you took it.
Try to focus on the present time, don't try to recapture anthing. If insomnia is persistant, then perhaps try the addition of Trazodone, which is a 5ht2a receptor antagonist, which can promote sleep, until your mood normalizes.
Are you taking Effexor right now ? I read an artical that said that rebound mania can actually be an temporary inflamitory reaction to the drug.
Try taking advil in addition to Effexor, for a few days, and see what this does. It's worth a shot.
Feel free to ask any more questions, cause
I think I had the same reaction you're having.
Linkadge
poster:linkadge
thread:288035
URL: http://www.dr-bob.org/babble/20031208/msgs/288135.html