Posted by john b stevens on December 1, 2003, at 21:30:43
In reply to Re: Buspar, posted by Questionmark on December 1, 2003, at 18:37:02
My undertanding is this: Serotonin gets released by the cell. Some of the serotonin feeds back on the 5ht1a autoreceptor; this receptor thus tells the cell 'we have enough serotonin, thank you' please stop making it. Buspar is technically a 5ht1a agonist, and thus it would seem that when it acts, the neuron would think that it should make less serotonin, as well. HOWEVER: Buspar is relative ANTAGONIST compared to serotonin. When the two molecules which are buspar and serotonin compete, buspar tells the receptor less loudly than serotonin itself does to shut down the making of serotonin; hence a relative increase compared to when buspar is not present.
poster:john b stevens
thread:285253
URL: http://www.dr-bob.org/babble/20031126/msgs/285729.html