Posted by Larry Hoover on December 1, 2003, at 16:06:07
In reply to Serzone (Nefazodone), posted by Mr. Scott on December 1, 2003, at 15:12:57
> Is anyone still using this drug? I heard about the rare liver stuff, but may have to try it anyways. Your sharing of any experiences with this chemical is appreciated.
>
> RichIt's the worst drug I ever took, but hey! you might get lucky.
The totally sucky liver failure thing is rare. More problematic is the fact that nefazodone is a powerful inhibitor of the liver cytochrome enzyme isoform 3A4....which is responsible for the breakdown and excretion of about 50% of all drugs, in whole or in part....the risk of interaction is substantial. Moreover, many drugs that are metabolized by 3A4 are also worked on by 2D6, and if you're a "poor metabolizer" (like me), that can spell real trouble. There is a genetic variability in 2D6 activity that varies by 100-fold or more, across the population. People with low 2D6 activity do not metabolize codeine well, for example (all side effects, little analgesia). If you have low 2D6 activity, and you block 3A4, you could end up with some severe liver injury. Make sure you check a table like the one at the following site, for possible drug interactions. Do not take tylenol when using this drug. If you're taking stuff that's not in the tables, do a google search on the drug name and 3A4, and see if it comes up as a substrate. Google likes keywords like 3A4, cause it's not a common "word".
Good luck,
Larhttp://www.erowid.org/psychoactives/pharmacology/pharmacology_enzymes1.shtml
poster:Larry Hoover
thread:285599
URL: http://www.dr-bob.org/babble/20031126/msgs/285613.html