Posted by SLS on November 8, 2003, at 16:07:26
In reply to Re: Lamictal vs. Depakote » amy_oz, posted by Dinah on November 7, 2003, at 10:18:00
Here's an excerpt from the Lamictal monograph posted at rxlist:
http://www.rxlist.com/cgi/generic/lamotrigine_cp.htm
"Valproate decreases the apparent clearance of lamotrigine (i.e., more than doubles the elimination half-life of lamotrigine), whether given with or without EIAEDs. Accordingly, if lamotrigine is to be administered to a patient receiving valproate, lamotrigine must be given at a reduced dosage, no more than half the dose used in patients not receiving valproate (see DOSAGE AND ADMINISTRATION and PRECAUTIONS: Drug Interactions)."
poster:SLS
thread:277175
URL: http://www.dr-bob.org/babble/20031105/msgs/277775.html