Posted by MamaB on October 21, 2003, at 16:41:26
In reply to Re: ¿VALCOTE sube los niveles plasmaticos de ZYPREXA?, posted by Bill LL on October 21, 2003, at 9:38:51
> I did some internet searches. It looks like Valcote (Depakote) is used in combination with Zyprexa. I copied a couple of articles.
>
> Thanks for the translation!
>
> 5. Double blind study to assess the safety and efficacy of valproic acid (Depakote®), an anticonvulsant, in combination with an atypical antipsychotic medication versus the use of either the antipsychotic alone in the treatment of psychosis in hospitalized patients with schizophrenia. During the four-week study, patients will be randomly assigned to one of four groups receiving the following medications: valproic acid plus risperidone (Risperdal®), valproic acid plus olanzapine (Zyprexa®), risperidone plus placebo, or olanzapine plus placebo.
>
>
>
> Figure 10 outlines the cost-benefit analysis for various agents used in bipolar disorders.
> Figure 10
> Valproic Acid (VPA)
> If GI Disturbance
> Divalproex
> (Depakote)
> Lithium
> Carbamazepine
> Geodon
> Equivalent Standards of Care
> Use of Agents for Bipolar Disorder
> (Cost-benefit Analysis))
> OR
> Risperdal
> ($0.17)
> ($1.36)
> OR
> Zyprexa
> Other
> Benzodiazepine
> Lorazepam
> (Ativan)
> ADD
> OR
> *
> *
> If needed, add
> Next
> Next
> Note: Sequential additional of
> drug based upon client's
> response
>
>
> > > ES CONOCIDO QUE LOS ANTICONVULSIVANTES , POR EJEMPLO CARBAMAZEPINA, BAJA LOS NIVELES PLASMATICOS DE OTRAS DROGAS ENTRE ELLAS ZYPREXA, SIN EMBARGO EN ALGUNA OPORTUNIDAD APRENDI QUE VALCOTE( DIVALPROATO DE SODIO ) SUBIRIA LOS NIVELES PLASMATICOS DE LA OLANZAPINA ( ZYPREXA ) , Y DE HECHO, EN MI PRACTICA CLINICA , DE ESA FORMA PUEDO NO AUMENTAR A DOSIS DEMASIADO ALTAS DE ZYPREXA, CUANDO EXISTEN PROBLEMAS ECONOMICOS ¿ ALGUIEN TIENE INFORMACION O CONOCIMIENTO DE LO QUE EXPONGO ? GRACIAS
> >
> > I'll take a stab at it ....
> >
> > It is known that anti-convulsants (sp), for example Carbamazepina, below the Plasmatic(?) levels of other drugs among them Zyprexa, although in some oportunity I learned that Valcote (???????? of sodium) will raise the plasmatic levels of Olanzapina (Zyprexa), therefore, in my clinical practice, in that way I can keep from raising the dosage of Zyprexa too much, when economic problems exist. Does anyone have information or knowledge of what I am proposing? Thanks.
> >
> >
> > Please be aware I have done a *literal* (word for word) translation for you which may or may not totally convey the essence of the message....Hopefully they will respond as you have asked.~~~8|8
>
>
Bill,
Can you share with me where you got the Information on valproic acid and the atypical antipsychotics? I would really appreciate it.
Applause to everyone who helped this fellow, that is what this board is about! MamaB
poster:MamaB
thread:270082
URL: http://www.dr-bob.org/babble/20031021/msgs/271578.html