Posted by Eddie Sylvano on October 3, 2003, at 19:49:54
In reply to Re: My grand theory about SSRI vs Tricyclics, posted by zeugma on October 3, 2003, at 19:09:09
I think that the tradional monoamine model tends to make people think within the confines of that handful of modulators. There are plenty of other chemicals at play, though. Nicotinic compounds, opiatelike compounds, GABA, glutamate, plenty o' hormones, nitric oxide, etc. The current drugs also don't just affect one transmitter, but initiate a cascade of effects, aftereffects, and similar changes when drug plasma levels drop and feedback loops come into play. It's a crazy, messy system that I think can only be modeled through the gathering and computer evaluation of lots and lots of information on chemical states at various stages in time. A computer is the only way to find useful patterns in the reams of seemingly disconnected events going on in the brain (or any natural system).
poster:Eddie Sylvano
thread:265309
URL: http://www.dr-bob.org/babble/20030928/msgs/265354.html