Perrine's Tricyclic Chart and a Preskorn Article

Posted by DSCH on September 21, 2003, at 16:28:29

In reply to Francesco » DSCH, posted by francesco on September 21, 2003, at 15:14:29

Source:
Perrine, Daniel M.
"The Chemistry of Mind-Altering Drugs: History, Pharmacology, and Cultural Context"
American Chemical Society, 1996, p. 235-7.
Amitriptyline (tertiary amine TC)
_Weight Gain: High
_Sedation: High
_Anticholinergic: High
_Hypotension: High
_Cardiotoxicity: High
Clomipramine (tertiary amine TC)
_Weight Gain: Medium
_Sedation: Medium
_Anticholinergic: High
_Hypotension: Medium
_Cardiotoxicity: High
Maprotiline (secondary amine TC)
_Weight Gain: Medium
_Sedation: Medium
_Anticholinergic: Medium
_Hypotension: Medium
_Cardiotoxicity: Medium
Doxepin (tertiary amine TC)
_Weight Gain: Medium
_Sedation: High
_Anticholinergic: Medium
_Hypotension: High
_Cardiotoxicity: Medium
Imipramine (tertiary amine TC)
_Weight Gain: Medium
_Sedation: Medium
_Anticholinergic: Medium
_Hypotension: Medium
_Cardiotoxicity: High

Amoxapine (secondary amine TC)
_Weight Gain: Medium
_Sedation: Low
_Anticholinergic: Low
_Hypotension: Medium
_Cardiotoxicity: Medium
Desipramine (secondary amine TC)
_Weight Gain: Medium
_Sedation: Low
_Anticholinergic: Low
_Hypotension: Low
_Cardiotoxicity: Medium
Nortriptyline (secondary amine TC)
_Weight Gain: Medium
_Sedation: Low
_Anticholinergic: Low
_Hypotension: Low
_Cardiotoxicity: Medium
-------------------------------------------------
OK... now for Dr. Preskorn
http://www.preskorn.com/columns/9803.html
Table 3 in particular!
-------------------------------------------------
Francesco:
Desipramine might be better for you than clomipramine. It inhibits reuptake of norepinepherine much more specifically than does imipramine. It also does not antagonize NE-alpha-1 and NE-alpha-2 receptors.

Thread

Re: Non-stimulant, Non-TCA for ADHD? « Francesco Dr. Bob 9/15/03
Francesco? » Dr. Bob DSCH 9/19/03
Francesco ! » DSCH Francesco 9/20/03
Re: Francesco ! » Francesco DSCH 9/21/03
Francesco » DSCH francesco 9/21/03
Perrine's Tricyclic Chart and a Preskorn Article DSCH 9/21/03
Secondary amine tricyclics for ADHD » francesco DSCH 9/21/03
Re: Perrine's Tricyclic Chart DSCH 9/21/03
Re: Francesco DSCH 9/23/03
Re: Francesco » DSCH francesco 9/23/03
Re: Francesco » francesco DSCH 9/23/03
Re: Francesco » DSCH Francesco 9/24/03
Re: Francesco Dr. Bob 9/24/03
news : ) » DSCH Francesco 9/26/03
Re: news : ) » Francesco DSCH 9/26/03
Re: news : ) » Francesco DSCH 9/26/03
Social babble self-redirect ;-) » Francesco DSCH 9/26/03
Re: thanks :-) (nm) » DSCH Dr. Bob 9/26/03
...
Re: Francesco! More on Tricyclics! » zeugma DSCH 10/11/03

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