Posted by tealady on September 13, 2003, at 8:00:14
In reply to Re: Ear scrreeeeeing » tealady, posted by EscherDementian on September 12, 2003, at 16:12:02
Well this is beyond my capabilites, so I'm hoping some one will jump right in and correct me, but here goes ..for a guess
I looked up http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html ..I got this reference from a post on this site
then I cut out all drugs that you or I have taken and put them together here
http://www.geocities.com/jan55qld/pdrugs.xls
The problem is , I am not sure and have no notes..and nor has my DOC!!! on when I got the ear ringing.
I'm assuming in late 98 and 99 is te period of the ear schreeeing, although I have always heard "high pitched motor type" noises..like the fridge nw I think of it and others cant..but that is a definite noise..
If so, I was "probably" on Lovan, an SSRI.., which has the same 5-HT reuptake inhibition +++ (which would mean strong level of) as your Lexapro....
So assuming this is right..
> It reduced in volume/level, after first quitting the Wellbutrin (still taking Lexapro), but not until later quitting the Lexapro for a week(cold turkey sudden stop once to test) did it really honestly start reducing.
>
> There was a period of a week&1/2 or so then i was taking Adderall ONLY and i was fine. No screeeing at all. Maybe soft ring'buzzing'(?), ?_maybe_?, but not disruptively noticeable.
>
> When the depression rollercoaster & head 'zaps' made Lexapro withdrawals terrifying & painful i went back on it and painful scrEEEEeeing returned. Reduced the dose immediately from 20mgs->10mgs. Still screEEeing disruptively, but volume reduced.
>
> After two weeks (and no alternative from PMHNP, who STILL negated my distress & insisted i stick with Lexapro but toiletflush remaining ADDerall), i halfed Lexapro dose again to 5mgs, only raising to 10mgs one or two times when the 'zaps' got real bad. If discontinuing ADDerall made any difference at all in volume/level, i couldn't have noticed: without Adderall i was miserably distracted by the continuous 'fingernail on chalkboard' effect.
>
> A couple weeks later, noticeable screeeing toned down to buzz to gone. UNTIL i made the mistake of drinking 12oz of microbrew (6%alcohol by volume) to try to calm down. SCUHREEEEEEEE!!! Yow! no more beer for me! Screeeing for the rest of the eve, then silence again waking the up the next morning. But in as much fatigue and depression as ever before - there's no benefit for me from Lexapro at this low dose.
>
> A week later, drank 2 glasses of microbrew at a b-b-q: >scuhREEEEEEEEE!!!< and the little Lexapro withdrawal'zaps' were now intensified. (i know, i know, no more beer!) ...but i know it's not that alone. Seems to be Lexapro residual IN COMBINATION. (like you too?)I didn't pay attention to whether it increased when I was drinkng or not.. I was assuming it was lack of sleep or noise causing it. It doesn't help when you mention it to your doc and it is glossed over, so in those days, I didn't realise it was related.
I definitely haven't had it since starting on T4/T3, and I don't get it with the tyrosine with the T3/T4..even with alcohol and lots of tyramines..Also I have my doubts about the chart I copied from, pretty sure it leaves lots out!
eg. I do think T3 affects acetylcholinerase..the enzyme that clears AcH from the synapses I think.. and don't ask me how that fits in... must do other things too that are not in that spreadsheet..or not known yet. I'm pretty certain T3 also affects serotonin....and That's not on the chart either..so it can't be relied on that much I guess.
If a lot of people had responded they took similar drugs and had the same symptoms..we'd have an answer...but it looks like it must be a combo, perhaps of having slightly lower than optimal thyroid function AND one of the drugs or alcohol and/or some stress?
In the meantime, what you just described is identical to what I had...it is nice to know that someone else in the world actually had the same thing, is it not?..not that I really want to wish it on anyone else ..but far better to know their is a cause, would be even better if one could pinpoint it
.
It is quite common amongst hypothyroid people, at least quite a no. responded that they had it and it went away with thyroid meds..perhaps that is also a link. I was not typical hypothyroid , but more borderline..so I would say sub-optimal and feeling symptoms, even if not reflected much in blood tests. I'm thinking you may be similar.
What I guess is it may be that for folks who are sub-optimal in thyroid function, then a strong 5-HT reuptake inhibitor could cause this? even maybe specifically a 5ht2c antagonist?
http://www.bentham.org/sample-issues/cmc9-8/spinks/spinks-ms.htm
I really don't know , but right now I am smiling that I ripped up my script for citalopram that endo gave me...this is what I want to find out..what one needs and what one should avoid.
BTW, do you have really good hearing usually? ..like acute hearing that can eavesdrop on conversations rooms away..or think the TV is too loud etc? That is a good sign of high serotonin..which one of the pathways I have no idea of.
Sorry, no much help, but I get lost with this stuff at presenT, so thoughts welcomed!
Just wanted you to know I was thinking on it
Jan
poster:tealady
thread:256096
URL: http://www.dr-bob.org/babble/20030912/msgs/259583.html