Posted by Larry Hoover on August 13, 2003, at 7:33:53
In reply to Re: PORPER COMBINATION OF VITAMINS AND MINERALS » Larry Hoover, posted by freedom2001 on August 11, 2003, at 23:51:03
> > A very comprehensive and balanced supplementation regime. I tip my hat to you. If you'll accept a couple comments....
>
> Hi Larry, actually these posts are taken from another website.I checked out Grimaldi's site. Pretty comprehensive, really. She supplies too much zinc in her supplements, though. Potentially toxic, in a child.
> I got a few questions for you though.
Questions! Cool.
> >
> > I'd generally recommend niacinamide over niacin, or at least, partitioned so that you get some niacinamide. Although they share some beneficial effects, their actions are also distinctive.
>
> Can you explain to me about the distinctive actions in more details?Niacin causes mast cell degranulation (histamine release), and induces prostaglandin E2 (off the top of my head, I think that's the one) synthesis. PGE2 is pro-inflammatory and is, in part, responsible for the niacin flush effect. Niacin also is capable of reducing blood cholesterol. It is generally thought to be excitatory (stimulating).
Niacinamide blocks mast cell degranulation, and PGE2 synthesis. It does not affect cholesterol. It also binds to the GABA receptor, and acts both as an agonist (it calms you like a mild benzo), and as a potentiator of your own GABA. There are other differences, but that's a start.
There is bound to be interconversion of the two forms, unless your enzymes are messed up. Enzymes don't know "direction"; although we usually think of a stream from niacin to niacinamide and on towards NADH, taking a bunch of niacinamide will cause some "back-conversion" to niacin, but the effect of the niacinamide will still be dominant. BTW, this may be why some people get the flush reaction from niacinamide; their enzymes are particularly effective in that conversion.
> >
> > >two capusles of 500 mg DHA/200 mg EPA and 1000 mg capsule of flax oil with borage oil. I have been advised that the oils are better absrobed on an empty stomach and in the absence of Ca or Mg.
> >
> > Fatty acid supplements are best absorbed when taken with a meal also high in other fats. When taken on an empty stomach, polyunsaturates are subject to possible oxidative cleavage from hydrochloric acid, yielding aldehydes and other products, and contributing to indigestion. When taken with a fatty meal, the other fats are sufficiently strong a signal to the gall bladder to release lipase and surfactants (bile), which substantially enhance fatty acid uptake in the intestine. Usually, the quantity of supplemental fatty acids (a few grams) is insufficient to trigger the release of lipase, on its own.
>
> I'm taking 3 softgels of high concentration fish oils every night with 25 mg of trazodone without meal. Is that okay?Your body's reactions supercede my advice.
> I'm already taking prozac, clonazepam, B, C and D Vitamins, Calcium, Magnesium and zinc along with meals to counter my OCD. I discovered that if I take fish oil along with all these at the same time, I will have stomach diarhhoea.
>
> What's your advice?Do what works for you. Taking fish oil on an empty stomach enhances the likelihood of "rancid fish burps". In the absence of food, your stomach acid is more likely to hydrolyze the triglycerides in the fish oil, yielding free fatty acids. Those free fatty acids can also undergo acid-catalyzed oxidation, yielding aldehydes with unpleasant characteristics. The presence of food would also dilute them, so it's kind of a double whammy.
You're still going to absorb a good proportion of the beneficial components of the fish oil, whether or not you take it with food, or whether or not you take it with other supplements. You have figured out a way to get your body to tolerate these supps, and I say, "Good for you."
I'd advise adding in some antioxidants, other than vitamin C. These might be: vitamin E, 400-800 IU/day; selenium, 200 mcg/day; alpha-lipoic acid, 50-200 mg/day.
Lar
poster:Larry Hoover
thread:250023
URL: http://www.dr-bob.org/babble/20030812/msgs/250486.html