Posted by DSCH on August 11, 2003, at 12:53:20
In reply to Re: Histamine and Hypersomniac Depression/ADD?, posted by Larry Hoover on August 11, 2003, at 4:54:10
> Every drug you mentioned in this thread is an antagonist, a substance that negates the effect of histamine. You'd need less, not more. However, I think that's a simplistic explanation, in any case (just like the serotonin imbalance explanation for depression).
Don't confuse the action of H1 and H3 antagonists. H3 antagonists are not "antihistamines" and cause *more* histamine to be released into the synpases, especially in the posterior hypothalamus. Take a peak at the abstracts you get if you run a search on "H3 antagonist". Activating effects rather than the classic sedation of antihistamines that cross the BBB.
poster:DSCH
thread:249973
URL: http://www.dr-bob.org/babble/20030807/msgs/250049.html