Posted by Mimi on August 7, 2003, at 11:55:27
In reply to Wellbutrin neurotoxicity?, posted by Ofan on August 7, 2003, at 3:21:51
> Greetings, all.
>
> I'm hoping someone more biochemically literate than I am can shed some light on a nagging question...
>
> I have recently started on Wellbutrin (I am concurrently taking Celexa for OCD, but it isn't doing enough for the depression I'm also experiencing.) One difficulty I have with switching or adding medications (and staying on them once switched) is a fear of drug toxicity.
>
> As is usual, I researched the drug as thoroughly as my limited knowledge of neurobiology allows. I discovered that bupropion is chemically rather similar to diethylpropion, a drug apparently used to treat obesity. Further research yielded
> several journal abstracts indicating a level of neurotoxicity associated with diethylpropion, related to oxidative stress and excitotoxicity.
>
> So here's the question: Given the chemical similarity between bupropion and diethylpropion, is it possible that bupropion might exhibit
> neurotoxicity as well?
>
> Anyone have any thoughts on this?Ofan,
Wellbutrin was definitely toxic to my system. My heart raced dangerously and I felt I would pass out. Needless to say, I axed that.
I do well on Celexa, but also take Seroquel for depression. Risperdal & Zyprexa work well also, though Zyprexa causes weight gain.
Mimi
poster:Mimi
thread:248841
URL: http://www.dr-bob.org/babble/20030807/msgs/248965.html