Posted by stjames on July 25, 2003, at 2:35:39
In reply to MDMA neurotoxicity » stjames, posted by mattdds on July 23, 2003, at 16:37:15
> Here's a good abstract on MDMA neurotoxicity, the evidence is building that this is some really nasty stuff to serotonergic neurons. I would urge you to rethink your decision to use it.
>I've read this one. the dose to the rats is HUGE.
Rat and human neurology are not the same thing.A great way to show toxic effects is with HUGE doses, with any substance.
Dear Dr. Shulgin:
Lately I've been hearing a lot of talk about how every time you take ecstasy it does permanent damage to the brain. I've also heard that ecstasy puts holes in the brain. Are these statements true?
-- Road Dog
http://www.cognitiveliberty.org/shulgin/adsarchive/brainholes.htmDear Road Dog:
No, they are not. The "permanent brain damage" is based totally on studies done with experimental animals, with the findings extrapolated to encompass the human subject. In a simple statement, there have been no studies in man that have indicated brain damage.
The "holes in the brain" is an even more outrageous deception. These popular holes are areas in brain scans that appear less active in attracting radiolabelled agents that are agonists for certain receptor site areas. The pictures that are shown for comparison are not of the same person with or without MDMA in them, but of different people, one of whom has used a lot of ecstasy and the other one without any such history. The quintessence of this line of mythology is an article that appeared recently in the Willamette Week. It not only assured the reader that there were holes generated by serotonin loss, but that they became flooded with dopamine (the default neurotransmitter) and, being attacked by hydrogen peroxide, produced rust.
Sorry, drug warriors. No damage, no holes, no rust.
-- Dr. Shulgin
poster:stjames
thread:243723
URL: http://www.dr-bob.org/babble/20030723/msgs/245094.html