Posted by Questionmark on June 24, 2003, at 1:39:48
In reply to PLEASE HELP ME...NEED MAOI/Mirapex suggestions, posted by indivmed on June 24, 2003, at 0:29:17
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> Hey Guys--
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> Okay, the Parnate seems to be less tiring that originally three weeks ago (I'm at 60 mg/day and might jump to 90 mg/day in two weeks or so). Of course, it could not be as tiring since I still take a small dose of Wellbutrin (I figure I would soon drop the dose of W.B. since I was working with someting that was a more potent dopamine agonist--Mirapex--not to mention that Provigil is potent in it's own ways. I take a Klonopin at night because I have always had severe nighttime anxiety (starting around 8 pm and going til the morning).
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> Does anyone know of people on this combination? Or parts of it? It must not be THAT crazy because my pdoc was fine with it and my vitals are fine...no real major side effects except some fatigue after my Mirapex dose--does the Mirapex (like the Parnate) become more stimulating over time?????
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> Right now, Mirapex puts my ass OUT!!! But I think it is helping my mood--I might start taking the full dose at night...do you have to take it in divided doses? What is the half-life...does it become more stimulating over time (such as Wellbutrin)? Provigil helps immensely to wake me up and get me motivated to start the day--I haven't gotten up this early in YEARS! I walked the dog in the park at 8:30 AM, did some research at the univ., got some sun, trained for a biathlon, made plans to be social with others, etc...this has NOT been me lately!!!!!!!!!!1
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> What I would like to do is stay on Parnate, Provigil, and Mirapex...wean off the Klonopin (which is temporary anyway). But if I continue to feel the lethargy I get from the Parnate and Mirapex (well, probably just the Mirapex now), I'm going to have to continue to augment with Wellbutrin.
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> Any doctors or psychopharmacologists (or pyshicatric laymen out there that see any overt major problems with this (other than a pretty large amount of dopamine that is not beng metabolized...then again, maybe that's been the problem the whole time!) I feel awkward having these meds approved to take so if you post, please me as constructive as possible--destructive criticism is something I'm not very good at handling (sorry, I'm sure most of you know what I mean).
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> PLEASE HELP AS I HAVE ASKED FOR INFORMATION ON THIS IN AT LEAST 28,000 DIFFERENT POSTS AND NO ONE ANSWERS AND I FEEL LIKE AN IDIOT, OR STUPID, OR THAT NO ONE LIKES ME (Hey, I never said I wasn't somewhat depressed still!).
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> Hope everyone is well,
> Rick
Sorry i havent commented earlier. i don't really know what to tell you.
But mAN are you getting a heck of a lot of dopamine stimulation, and general CNS stimulation. It's weird that your bothersome side effect is still fatigue and not horrendous anxiety. It's possible that since you raised your Parnate dose so fast you are still getting fatigue from that-- but if so i'm pretty sure that subsides with time. i have also heard of Mirapex being fatiguing at first as well (but only temporarily), though i am not sure. So that should get better with time also.
i know you like to increase your med dose really fast, but i would really suggest trying not to do that. Your brain (& body) needs time to adjust to the drug, and too much too fast is much more likely to cause problems i believe. It might even be not-quite-good for your brain. It's sensitive as heck. But i can understand wanting stuff to kick in faster and not wanting to wait what seems like eternities. But even in the long run (and certainly in the short-- dealing w/ side effects & what not) i think it's more counterproductive. i wish i could give you more specific advice, but i don't identify with your brain (or whatever)-- on 60mg Parnate PLUS Wellbutrin would be wayy too much for me, let alone the added Mirapex AND Provigil. Damn.
i might drop the Well. altogether-- it's too unpredictable and complex, at least for me.
Okay, well i hope you feel better for a lifetime. Take care and be kind.
poster:Questionmark
thread:232905
URL: http://www.dr-bob.org/babble/20030619/msgs/236563.html