Posted by Larry Hoover on June 15, 2003, at 21:48:51
In reply to What the heck is going on here!? Ace needs advice!, posted by ace on June 15, 2003, at 20:17:10
> Hmmm...I'm not a happy man at the moment.
>
> It's to do with Nardil...
>
> Here's the situation...
>
> I foolishly stopped Nardil to foolishly try Anafranil. I WAS FOOLISHLY OFF NARDIL 17 DAYS IN TOTAL. Anyway, I restarted Nardil ASAP - even at the risk of 5HT syndrome - I resatrted only 2 days after 4 days of foolishly starting Anafranil.
>
>
> Anyhow, one I reached 60mg, after a few days on 15/30/45 it kicked in BIG TIME! But this frittered away and I began feeling flat - anyhow I have been on 90mg for 5 days now - still feeling flat a lot of the time, BUT IT IS WORKING GREAT FOR THE Phobic anxiety/derealization.
>
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> So essentially, that 17 days off the magic...it's like I've had to start again...last time it took 6 weeks to kick in... I have now been on it for 4 and a half weeks. And ALL of the s/effects when I first went on it have come back! Some are starting to fade however...
>
> Within that 17 days would resynthesis occured?Yup. MAO enzymes have a half-life of less than two weeks. With an irreversible inhibitor like phenelzine, there may well be an upregulation of MAO synthesis, as the body tries to overcome the drug's effect. By going off the drug for 17 days, you probably came close to 100% restoration of your normal MAO complement, if not reaching it sooner. If you had fully reached your normal level of the enzyme, feed-back inhibition would already be occurring. In other words, you'd have to start all over again with the Nardil. There's a good chance your body remains primed to attempt to circumvent the drug. This is just my opinion.
> But why is it working great for derealization/anxiety now...will i have to wait again for the depression effects.
Soon, you'll feel that again. You need greater than 80% inhibition of MAO.
> You stupid FOOL Andrew for going off the stuff! You FOOL! You FOOL! You FOOL!
>
> Ace,
>
> PS please call me a fool!You were not, and are not, a fool. You were trying to help yourself feel well. Only in hindsight can you come to any negative opinion, so why bother with that?
Hope the Nardil kicks in soon.
Lar
poster:Larry Hoover
thread:234198
URL: http://www.dr-bob.org/babble/20030614/msgs/234207.html